allele frequencies of hla class-i loci in the normal iranian population
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abstract
introduction: human leukocyte antigen (hla) genes are the most polymorphic loci in the human genome. they predict the outcome of transplantation by detecting self from non-self antigens. the best use of hla typing is to find a hla-match donor for bmt candidate patients. evidence suggests that matching unrelated donors and recipients for hla-a, -b and -drb1 loci is a prediction for an improved outcome. methods and materials: hla-a and -b of six hundred iranian cord blood samples were typed by pcr-ssp method and the frequency of loci were estimated. results: the most frequent alleles were a*02(18.16), a*24(16.41), b*35(21.66) and b*51(13.35), respectively. discussion: our hla typing data show similarity between neighbor and related countries and caucasians. identifying hla alleles helps to find suitable donors for patients in need of hematopoietic stem cell transplantation.
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Journal title:
international journal of hematology-oncology and stem cell researchجلد ۳، شماره ۲، صفحات ۱۸-۲۰
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